Santos, L. P., Gigante, D. P., Delpino, F. M., Maciel, A. P. & Bielemann, R. M. Sugar sweetened beverages intake and risk of obesity and cardiometabolic diseases in longitudinal studies: a systematic review and meta-analysis with 1.5 million individuals. Clin. Nutr. ESPEN 51, 128–142 (2022).
Google Scholar
Li, X. et al. Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women. Am. J. Clin. Nutr. 117, 490–498 (2023).
Google Scholar
Khan, T. A., Chiavaroli, L., Zurbau, A. & Sievenpiper, J. L. A lack of consideration of a dose-response relationship can lead to erroneous conclusions regarding 100% fruit juice and the risk of cardiometabolic disease. Eur. J. Clin. Nutr. 73, 1556–1560 (2019).
Google Scholar
Scheffers, F. R. et al. Pure fruit juice and fruit consumption and the risk of CVD: the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) study. Br. J. Nutr. 121, 351–359 (2019).
Google Scholar
Zurbau, A. et al. Relation of different fruit and vegetable sources with incident cardiovascular outcomes: a systematic review and meta-analysis of prospective cohort studies. J. Am. Heart Assoc. 9, e017728 (2020).
Google Scholar
Ferreira-Pego, C. et al. Frequent consumption of sugar- and artificially sweetened beverages and natural and bottled fruit juices is associated with an increased risk of metabolic syndrome in a mediterranean population at high cardiovascular disease risk. J. Nutr. 146, 1528–1536 (2016).
Google Scholar
Auerbach, B. J. et al. Associations of 100% fruit juice versus whole fruit with hypertension and diabetes risk in postmenopausal women: Results from the Women’s Health Initiative. Prev. Med. 105, 212–218 (2017).
Google Scholar
Chiavaroli, L. et al. Important food sources of fructose-containing sugars and adiposity: a systematic review and meta-analysis of controlled feeding trials. Am. J. Clin. Nutr. 117, 741–765 (2023).
Google Scholar
Malik, V. S. & Hu, F. B. The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases. Nat. Rev. Endocrinol. 18, 205–218 (2022).
Google Scholar
Zhang, Z. et al. A prospective study of fruit juice consumption and the risk of overall and cardiovascular disease mortality. Nutrients (2022).
Chen, V. et al. Relation of fruit juice with adiposity and diabetes depends on how fruit juice is defined: a re-analysis of the EFSA draft scientific opinion on the tolerable upper intake level for dietary sugars. Eur. J. Clin. Nutr. 77, 699–704 (2023).
Google Scholar
Boutagy, N. E., McMillan, R. P., Frisard, M. I. & Hulver, M. W. Metabolic endotoxemia with obesity: Is it real and is it relevant? Biochimie 124, 11–20 (2016).
Google Scholar
Mohammad, S. & Thiemermann, C. Role of metabolic endotoxemia in systemic inflammation and potential interventions. Front Immunol. 11, 594150 (2020).
Google Scholar
Jialal, I., Kaur, H. & Devaraj, S. Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J. Clin. Endocrinol. Metab. 99, 39–48 (2014).
Google Scholar
Kanuri, G. et al. Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease. Liver Int. 35, 562–568 (2015).
Google Scholar
Ahmad, R. et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J. Inflamm. 9, 48 (2012).
Google Scholar
Miura, K. et al. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology 57, 577–589 (2013).
Google Scholar
Spruss, A. et al. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 50, 1094–1104 (2009).
Google Scholar
Guo, Z., Zhang, Y., Liu, C., Youn, J. Y. & Cai, H. Toll-like receptor 2 (TLR2) knockout abrogates diabetic and obese phenotypes while restoring endothelial function via inhibition of NOX1. Diabetes 70, 2107–2119 (2021).
Google Scholar
Nier, A., Brandt, A., Rajcic, D., Bruns, T. & Bergheim, I. Short-term isocaloric intake of a fructose- but not glucose-rich diet affects bacterial endotoxin concentrations and markers of metabolic health in normal weight healthy subjects. Mol. Nutr. Food Res 63, e1800868 (2019).
Google Scholar
Staltner, R., Sanchez, V., Bergheim, I. & Baumann, A. Acute intake of sucrose but not of the intense sweetener sucralose is associated with post-prandial endotoxemia in healthy young adults—a randomized controlled trial. Nutrients (2023).
Andre, P., Laugerette, F. & Feart, C. Metabolic endotoxemia: a potential underlying mechanism of the relationship between dietary fat intake and risk for cognitive impairments in humans? Nutrients (2019).
Malesza, I. J. et al. High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review. Cells (2021).
Deusser, H. et al. Gastrointestinal absorption and metabolism of apple polyphenols ex vivo by the pig intestinal mucosa in the Ussing chamber. Biotechnol. J. 8, 363–370 (2013).
Google Scholar
Kahle, K. et al. Intestinal transit and systemic metabolism of apple polyphenols. Eur. J. Nutr. 50, 507–522 (2011).
Google Scholar
Singh, A., Yau, Y. F., Leung, K. S., El-Nezami, H. & Lee, J. C. Interaction of polyphenols as antioxidant and anti-inflammatory compounds in brain-liver-gut axis. Antioxidants (2020).
Barth, S. W. et al. Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 26, 1414–1421 (2005).
Google Scholar
Schaefer, S. et al. Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines. Mol. Nutr. Food Res. 50, 24–33 (2006).
Google Scholar
Pelsers, M. M. et al. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. Clin. Biochem. 36, 529–535 (2003).
Google Scholar
Tabung, F. K. et al. Influence of dietary patterns on plasma soluble CD14, a surrogate marker of gut barrier dysfunction. Curr. Dev. Nutr. (2017).
Ramne, S. et al. Gut microbiota composition in relation to intake of added sugar, sugar-sweetened beverages and artificially sweetened beverages in the Malmo Offspring Study. Eur. J. Nutr. 60, 2087–2097 (2021).
Google Scholar
Satokari, R. High intake of sugar and the balance between pro- and anti-inflammatory gut bacteria. Nutrients (2020).
statista. Per Capita Consumption of Apple Juice in Germany From 2005 to 2022, (2024).
Mosler, S. C. et al. Flüssigkeitsmanagement im Sport: Position der Arbeitsgruppe Sporternährung der Deutschen Gesellschaft für Ernährung eV (DGE). Ernährungs-Umsch. 66, 52–59 (2019).
Andre, P. et al. Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults. Am. J. Clin. Nutr. 114, 1080–1091 (2021).
Google Scholar
Dube, N. et al. Modulation of intestinal and liver fatty acid-binding proteins in Caco-2 cells by lipids, hormones and cytokines. J. Cell Biochem. 81, 613–620 (2001).
Google Scholar
Jung, F. et al. Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs. Eur. J. Nutr. 61, 4155–4166 (2022).
Google Scholar
Landmann, R. et al. Human monocyte CD14 is upregulated by lipopolysaccharide. Infect. Immun. 64, 1762–1769 (1996).
Google Scholar
Ghanim, H. et al. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am. J. Clin. Nutr. 91, 940–949 (2010).
Google Scholar
Bergheim, I. et al. Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J. Hepatol. 48, 983–992 (2008).
Google Scholar
Staltner, R., Burger, K., Baumann, A. & Bergheim, I. Fructose: a modulator of intestinal barrier function and hepatic health? Eur. J. Nutr. (2023).
Zhang, X. et al. Glucose but not fructose alters the intestinal paracellular permeability in association with gut inflammation and dysbiosis in mice. Front. Immunol. 12, 742584 (2021).
Google Scholar
Lee, Y. C., Cheng, C. W., Lee, H. J. & Chu, H. C. Apple polyphenol suppresses indomethacin-induced gastric damage in experimental animals by lowering oxidative stress status and modulating the MAPK signaling pathway. J. Med. Food 20, 1113–1120 (2017).
Google Scholar
Volstatova, T. et al. Effects of chlorogenic acid, epicatechin gallate, and quercetin on mucin expression and secretion in the Caco-2/HT29-MTX cell model. Food Sci. Nutr. 7, 492–498 (2019).
Google Scholar
Wu, H. et al. Granny Smith apple procyanidin extract upregulates tight junction protein expression and modulates oxidative stress and inflammation in lipopolysaccharide-induced Caco-2 cells. Food Funct. 9, 3321–3329 (2018).
Google Scholar
Vreeburg, R. A., van Wezel, E. E., Ocana-Calahorro, F. & Mes, J. J. Apple extract induces increased epithelial resistance and claudin 4 expression in Caco-2 cells. J. Sci. Food Agric. 92, 439–444 (2012).
Google Scholar
Kagawa, T. & Yamaoka, I. Intragastric infusion of a liquid diet with low-methoxyl pectin alleviates fecal inconsistency and local proinflammatory cytokine expression in lipopolysaccharide-septic rats. Nutrition 118, 112271 (2024).
Google Scholar
Sherry, C. L. et al. Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization. Brain Behav. Immun. 24, 631–640 (2010).
Google Scholar
Prado, S. B. R. et al. Pectin interaction with immune receptors is modulated by ripening process in papayas. Sci. Rep. 10, 1690 (2020).
Google Scholar
Beukema, M., Faas, M. M. & de Vos, P. The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells. Exp. Mol. Med. 52, 1364–1376 (2020).
Google Scholar
Dang, G. et al. Pectin supplement alleviates gut injury potentially through improving gut microbiota community in piglets. Front. Microbiol. 13, 1069694 (2022).
Google Scholar
Wen, X. et al. Pectin supplementation ameliorates intestinal epithelial barrier function damage by modulating intestinal microbiota in lipopolysaccharide-challenged piglets. J. Nutr. Biochem 109, 109107 (2022).
Google Scholar
Paderin, N. M., Polugrudov, A. S., Khramova, D. S. & Popov, S. V. Effect of pectin gel particles on endotoxemia induced by restraint stress in mice. Bull. Exp. Biol. Med. 163, 419–421 (2017).
Google Scholar
Iametti, S., Bonomi, F. & Di Nunzio, M. Dietary polyphenols and in vitro intestinal fructose uptake and transport: a systematic literature review. Int. J. Mol. Sci. (2022).
Prior, R. L., Wu, X. & Schaich, K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J. Agric Food Chem. 53, 4290–4302 (2005).
Google Scholar
IFU. List of All Methods. (2024).
Lebensmittelsicherheit, B. f. V. u. Amtliche Sammlung von Untersuchungsverfahren (ASU) gemäß § 64 LFGB. (2024).
Jung, F. et al. Markers of intestinal permeability are rapidly improved by alcohol withdrawal in patients with alcohol-related liver disease. Nutrients (2021).
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